Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer
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چکیده
منابع مشابه
KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.
BACKGROUND Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo melanoma cell suppresses their ability to metastasize by at least 95% without affecting their tumorigenicity. This observation demonstrates that the ability to metastasize is a phenotype distinct from tumor formation and suggests that tumorigenic cells acquire metastatic capability only after accumulating additi...
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Notch1 is a type-1 transmembrane receptor which has been demonstrated to be involved in proliferation in various organisms. A number of studies have proposed that Notch signaling may be aberrantly activated, thus contributing to development, invasion and metastasis in a variety of human cancers. In the present study, the function and mechanism of Notch1 in human prostate cancer (PCa) LNCaP cell...
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The expression of the metastasis suppressor gene KISS-1 in osteosarcoma cells during apoptosis and autophagy was evaluated. MG-63 osteosarcoma cells were transfected with either KISS-1 overexpression or KISS-1 knockdown expression vector in vitro, and compared with cell lines transfected with empty vector. After 12, 24, 48 and 72 h of cell culture, the cell proliferation was examined. The MTT m...
متن کاملSuppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1.
Based on the observation that chromosome 1q deletions are not infrequent in late-stage human breast carcinomas, we tested whether the recently discovered human melanoma metastasis suppressor gene, KiSS-1, which maps to chromosome 1q32-q41, could suppress metastasis of the human breast carcinoma cell line MDA-MB-435. Parental, vector-only transfectants and KiSS-1 transfectant clones were injecte...
متن کاملThe Role of Kisspeptins (KiSS-1) in Breast Cancer Therapy: the Essential Kiss of Life
The most common malignancy among Indian women is breast cancer. Patient’s ages ranging between 35 40 yrs old at diagnosis are usually considered as the endangered population [1].Breast cancer in women below 40 years is not a usual condition. However, a sudden increase in the incidence of breast cancers in premenopausal women has been reported from several countries. Though adjuvant combination ...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2014
ISSN: 1471-2407
DOI: 10.1186/1471-2407-14-723